Screening assessment on MBMBP phenols: appendix 2


Appendix 2: Summary of Health Effects Information for MBMBP

Endpoint Lowest effect levelsFootnote a/Results
Acute toxicity Lowest oral LD50(mouse) = 3200 mg/kg-bw (Ashland Oil Inc. 1992)

[Additional studies: Hagan 1952; Stasenkova et al. 1977; Sumitomo Chemical Co Ltd. 1977a; ACC 1988; Bayer AG 1988; Takagi et al. 1994; HSDB 1998]

Lowest dermal LD50(rabbit) >10 000 mg/kg-bw (ACC 1988)
Short-term repeated-dose toxicity Lowest oral (gavage) LOEL (rat) = 50 mg/kg-bw per day: prolongation of prothrombin time, increased liver weight, degeneration of spermatids and vacuolation of Sertoli cells (28- and 53-day studies) (MHW 1996, 1999)

[Additional studies: Hagan 1952; Takahashi and Hiraga 1981a, 1981b; Ashland Oil Inc. 1992]
Subchronic toxicity Lowest oral (diet) LOEL (dog) = 6 mg/kg-bw per day: change in alkaline phosphatase activity (90-day study) (ACC 1965b)

[Additional studies: ACC 1965a; Takagi et al. 1994]
Chronic toxicity/ carcinogenicity Lowest non-neoplastic oral (diet) LOEL (rat) = 12.7 mg/kg-bw per day: increased relative liver weight (18-month study); no increases in tumour incidence observed in rats exposed to up to 42.3 mg/kg-bw per day for 18 months (Takagi et al. 1994)
Genotoxicity and related endpoints: in vitro Negative: Mutagenicity in Salmonella typhimurium TA98, TA100, TA1535 and TA1537 and Escherichia coli (Sumitomo Chemical Co Ltd. 1977b; Yamaguchi et al. 1991; MHW 1996), chromosomal aberrations in Chinese hamster lung cells (MHW 1996), DNA damage in Bacillus subtilis (Sumitomo Chemical Co Ltd. 1977b)

Positive: Cell transformation in BALB/c3T3 cells and promotion in Chinese hamster V79 lung fibroblasts (Tsuchiya et al. 1995)
Developmental toxicity Lowest oral (gavage) LOEL (fetal rat) = 375 mg/kg-bw per day: increase in fetal deaths; LOEL (maternal) = 187 mg/kg-bw per day: decreased body weight gain (exposure during gestation days 7-17) (Tanaka et al. 1990)

[Additional studies: Telford et al. 1962; MHW 1999]
Reproductive toxicity Lowest oral (diet) LOEL (male rat) = 42.3 mg/kg-bw per day: decreased absolute and relative testis weights, testis tubule atrophy and decreased spermatogenesis (18-month study) (Takagi et al. 1994)

[Additional studies: MHW 1996, 1999]

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